Novel Sulfamide-Containing Compounds as Selective Carbonic Anhydrase I Inhibitors
نویسندگان
چکیده
منابع مشابه
Novel Sulfamide-Containing Compounds as Selective Carbonic Anhydrase I Inhibitors.
The development of isoform selective inhibitors of the carbonic anhydrase (CA; EC 4.2.1.1) enzymes represents the key approach for the successful development of druggable small molecules. Herein we report a series of new benzenesulfamide derivatives (-NH-SO₂NH₂) bearing the 1-benzhydrylpiperazine tail and connected by means of a β-alanyl or nipecotyl spacer. All compounds 6a-l were investigated...
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1Department of Pharmaceutical Sciences and Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad, Pakistan 2Department of Chemistry, Forman Christian College (A Chartered University), Ferozepur Road, Lahore 54600, Pakistan 3Division of Biophysics, Department of Basic Medical Sciences, School of Medicine, Bahçeşehir University, Turkey 4Institute of Biostructu...
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The interaction of carbonic anhydrase (CA) isozymes I and II with a series of As(III) derivatives, dialkyl and diaryl rac-2,3-dimyristoyloxypropyldithioarsonites, was investigated kinetically and spectrophotometrically, utilizing the native and Co(II)-substituted enzymes. Depending on the substitution pattern at the -As(SR)(2) moiety of the investigated derivatives, inactive compounds were foun...
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ژورنال
عنوان ژورنال: Molecules
سال: 2017
ISSN: 1420-3049
DOI: 10.3390/molecules22071049